Structured Summary
Abstract
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.
MeSH Record
Classification
Broader headings
Narrower headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
Synonyms
1 entry terms
- Topoisomerases, DNA
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2002
MeSH Record
Previous Indexing
- DNA Topoisomerase (1977-2001)
- DNA Topoisomerase (ATP-Hydrolysing) (1979-2001)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QU 137
AMA Style
References
- National Library of Medicine. DNA Topoisomerases. Medical Subject Headings (MeSH). 2026. Unique ID D026942. http://id.nlm.nih.gov/mesh/2026/D026942
- DNA Topoisomerases. In: Wikipedia. https://en.wikipedia.org/wiki/Topoisomerase
- DNA Topoisomerases. In: Wikidata. https://www.wikidata.org/wiki/Q407828