Structured Summary
Abstract
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
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Synonyms
36 entry terms
- DNA Nicking-Closing Protein
- DNA Nicking-Closing Proteins
- DNA Relaxing Enzyme
- DNA Relaxing Enzymes
- DNA Relaxing Protein
- DNA Topoisomerase
- DNA Topoisomerase I
- DNA Topoisomerases, Type I
- DNA Type 1 Topoisomerase
- DNA Untwisting Enzyme
- DNA Untwisting Enzymes
- DNA Untwisting Protein
- DNA Untwisting Proteins
- Topoisomerase I
- Type I DNA Topoisomerase
- DNA Topoisomerase III
- DNA Topoisomerase III alpha
- DNA Topoisomerase III beta
- TOP3 Topoisomerase
- TOP3alpha
- TOPO IIIalpha
- Topo III
- Topoisomerase III
- Topoisomerase III beta
- Topoisomerase IIIalpha
- Topoisomerase IIIbeta
- III beta, Topoisomerase
- III, DNA Topoisomerase
- III, Topo
- III, Topoisomerase
- IIIalpha, TOPO
- IIIalpha, Topoisomerase
- IIIbeta, Topoisomerase
- Topoisomerase III, DNA
- Topoisomerase, TOP3
- beta, Topoisomerase III
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent
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History Note
2002
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Previous Indexing
- DNA, Circular (1973-1977)
- Deoxyribonucleases (1966-1977)
- Polynucleotide Synthetases (1973-1977)
- Proteins (1966-1977)
- specific protein (1966-1977)
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References
- National Library of Medicine. Type I DNA Topoisomerases. Medical Subject Headings (MeSH). 2026. Unique ID D004264. http://id.nlm.nih.gov/mesh/2026/D004264
- Type I DNA Topoisomerases. In: Wikipedia. https://en.wikipedia.org/wiki/Type_I_topoisomerase
- Type I DNA Topoisomerases. In: Wikidata. https://www.wikidata.org/wiki/Q7860880