Chemicals and Drugs

Dabigatran

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.

Chemical Identity

Chemical Information

Molecular Formula
C25H25N7O3
Molecular Weight
471.5 g/mol
CAS Registry No.
211914-51-1
IUPAC Name
3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
InChIKey
YBSJFWOBGCMAKL-UHFFFAOYSA-N
SMILES
CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
MeSH Unique ID
D000069604
Source
PubChem CID 216210

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine
  • BIBR 1048
  • Dabigatran Etexilate
  • Dabigatran Etexilate Mesylate
  • Pradaxa
  • Etexilate Mesylate, Dabigatran
  • Etexilate, Dabigatran
  • Mesylate, Dabigatran Etexilate

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2002)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.725w.192w
  2. D03w.633.100.103.280w

AMA Style

References

  1. National Library of Medicine. Dabigatran. Medical Subject Headings (MeSH). 2026. Unique ID D000069604. http://id.nlm.nih.gov/mesh/2026/D000069604
  2. Dabigatran. In: Wikipedia. https://en.wikipedia.org/wiki/Dabigatran
  3. Dabigatran. In: Wikidata. https://www.wikidata.org/wiki/Q419345
  4. Dabigatran. In: PubChem Compound. CID 216210. https://pubchem.ncbi.nlm.nih.gov/compound/216210