Structured Summary
Abstract
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
Chemical Identity
Chemical Information
- Molecular Formula
- C14H10N4O5
- Molecular Weight
- 314.25 g/mol
- IUPAC Name
- 1-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
- InChIKey
- OZOMQRBLCMDCEG-UHFFFAOYSA-N
- SMILES
- C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]
- MeSH Unique ID
- D003620
- Source
- PubChem CID 2952
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
3 entry terms
- Dantrium
- Dantrolene Sodium
- Sodium, Dantrolene
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
80(75); was see under HYDANTOINS 1975-79
MeSH Record
Previous Indexing
- Hydantoins (1966-1974)
MeSH Hierarchy
Tree Number
MeSH Record
NLM Classification
QV 140
AMA Style
References
- National Library of Medicine. Dantrolene. Medical Subject Headings (MeSH). 2026. Unique ID D003620. http://id.nlm.nih.gov/mesh/2026/D003620
- Dantrolene. In: Wikipedia. https://en.wikipedia.org/wiki/Dantrolene
- Dantrolene. In: Wikidata. https://www.wikidata.org/wiki/Q421274
- Dantrolene. In: PubChem Compound. CID 2952. https://pubchem.ncbi.nlm.nih.gov/compound/2952