Phenomena and Processes

Death Domain Superfamily

A family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Death-Like Domain
  • Death-Like Domains
  • Death Domain Superfamilies
  • Death Like Domain
  • Death Like Domains
  • Domain Superfamilies, Death
  • Domain Superfamily, Death
  • Superfamilies, Death Domain
  • Superfamily, Death Domain

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Amino Acid Sequence (2001-2016)
  • Apoptosis (2001-2016)
  • Molecular Sequence Data (2001-2016)
  • Protein Structure, Tertiary (2007-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.500.395

AMA Style

References

  1. National Library of Medicine. Death Domain Superfamily. Medical Subject Headings (MeSH). 2026. Unique ID D000071458. http://id.nlm.nih.gov/mesh/2026/D000071458
  2. Death Domain Superfamily. In: Wikidata. https://www.wikidata.org/wiki/Q70711319