Chemicals and Drugs

Discoidin Domain Receptors

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • DDR Proteins
  • Discoidin Domain Receptor
  • Proteins, DDR
  • Receptor, Discoidin Domain
  • Receptors, Discoidin Domain

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2017 (1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.005
  2. D12.776w.476.568w.400w.005
  3. D12.776w.543w.750w.630w.005
  4. D12.776w.543w.750w.685w.050
  5. D12.776w.543w.750w.705w.880.300

AMA Style

References

  1. National Library of Medicine. Discoidin Domain Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D000070818. http://id.nlm.nih.gov/mesh/2026/D000070818
  2. Discoidin Domain Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q78049496