Chemicals and Drugs

Dizocilpine Maleate

A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

Chemical Identity

Chemical Information

Molecular Formula
C20H19NO4
Molecular Weight
337.4 g/mol
CAS Registry No.
77086-22-7
IUPAC Name
(Z)-but-2-enedioic acid;(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
InChIKey
QLTXKCWMEZIHBJ-PJGJYSAQSA-N
SMILES
C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O
MeSH Unique ID
D016291
Source
PubChem CID 6420042

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

4 entry terms
  • Dizocilpine
  • MK-801
  • MK 801
  • MK801

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Anticonvulsants (1966-1990)
  • Dibenzocycloheptenes (1968-1990)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.181w.384.380
  2. D04w.615w.181w.384.380

AMA Style

References

  1. National Library of Medicine. Dizocilpine Maleate. Medical Subject Headings (MeSH). 2026. Unique ID D016291. http://id.nlm.nih.gov/mesh/2026/D016291
  2. Dizocilpine Maleate. In: Wikidata. https://www.wikidata.org/wiki/Q27265120
  3. Dizocilpine Maleate. In: PubChem Compound. CID 6420042. https://pubchem.ncbi.nlm.nih.gov/compound/6420042