Chemicals and Drugs

Domperidone

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Chemical Identity

Chemical Information

Molecular Formula
C22H24ClN5O2
Molecular Weight
425.9 g/mol
CAS Registry No.
57808-66-9
IUPAC Name
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
InChIKey
FGXWKSZFVQUSTL-UHFFFAOYSA-N
SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
MeSH Unique ID
D004294
Source
PubChem CID 3151

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

34 entry terms
  • Domperidon
  • Apo-Domperidone
  • Domidon
  • Domperidon AL
  • Domperidon Hexal
  • Domperidon Stada
  • Domperidon-TEVA
  • Domperidona Gamir
  • Domperidone Maleate
  • Domperidone Maleate (1:1)
  • Domperidone Monohydrochloride
  • Gastrocure
  • Motilium
  • Nauzelin
  • Novo-Domperidone
  • Nu-Domperidone
  • PMS-Domperidone
  • Péridys
  • R-33,812
  • R-33812
  • Ratio-Domperidone
  • Apo Domperidone
  • Domperidon TEVA
  • Gamir, Domperidona
  • Hexal, Domperidon
  • Maleate, Domperidone
  • Monohydrochloride, Domperidone
  • Novo Domperidone
  • Nu Domperidone
  • PMS Domperidone
  • R33,812
  • R33812
  • Ratio Domperidone
  • Stada, Domperidon

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

82

MeSH Record

Previous Indexing

  • Antiemetics (1977-1981)
  • Benzimidazoles (1977-1981)
  • Piperidines (1977-1981)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.621.210w
  2. D03w.633.100.103.370w

AMA Style

References

  1. National Library of Medicine. Domperidone. Medical Subject Headings (MeSH). 2026. Unique ID D004294. http://id.nlm.nih.gov/mesh/2026/D004294
  2. Domperidone. In: Wikipedia. https://en.wikipedia.org/wiki/Domperidone
  3. Domperidone. In: Wikidata. https://www.wikidata.org/wiki/Q424238
  4. Domperidone. In: PubChem Compound. CID 3151. https://pubchem.ncbi.nlm.nih.gov/compound/3151