Chemicals and Drugs

Edar-Associated Death Domain Protein

A tumor necrosis factor receptor-associated factor that acts as a specific signaling adaptor protein for the EDAR RECEPTOR and plays an important role in ectodermal development. It binds to edar receptor via its C-terminal death domain region and to other specific TNF receptor-associated factors via its N-terminal domain. Loss of function of edar-associated death domain protein is associated with AUTOSOMAL RECESSIVE ANHIDROTIC ECTODERMAL DYSPLASIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tumor necrosis factor receptor-associated factor that acts as a specific signaling adaptor protein for the EDAR RECEPTOR and plays an important role in ectodermal development. It binds to edar receptor via its C-terminal death domain region and to other specific TNF receptor-associated factors via its N-terminal domain. Loss of function of edar-associated death domain protein is associated with AUTOSOMAL RECESSIVE ANHIDROTIC ECTODERMAL DYSPLASIA.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

2 entry terms
  • Edaradd Protein
  • Edar Associated Death Domain Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007(2002)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.285.100
  2. D12.644w.360.024w.500w.061
  3. D12.644w.360.075.421.100
  4. D12.776w.157w.057w.018.100
  5. D12.776w.157w.057w.500w.061
  6. D12.776w.476.024w.320.100
  7. D12.776w.476.024w.500w.061
  8. D12.776w.476.075.421.100

AMA Style

References

  1. National Library of Medicine. Edar-Associated Death Domain Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053362. http://id.nlm.nih.gov/mesh/2026/D053362
  2. Edar-Associated Death Domain Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21115840