Phenomena and Processes

Endoplasmic Reticulum-Associated Degradation

A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A degradation process whereby incorrectly folded proteins are selectively transported out of the ENDOPLASMIC RETICULUM and into the CYTOSOL. The misfolded proteins are subsequently ubiquitinated and degraded by the PROTEASOME.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • ERAD Pathway
  • Degradation, Endoplasmic Reticulum-Associated
  • ERAD Pathways
  • Endoplasmic Reticulum Associated Degradation
  • Pathway, ERAD
  • Pathways, ERAD
  • Reticulum-Associated Degradation, Endoplasmic

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2012

MeSH Record

Previous Indexing

  • Protein Folding (1995-2011)

MeSH Hierarchy

Tree Numbers

  1. G02.111.660.871w.790.600w.962w.500w
  2. G02.111.691.600w.850w.500w
  3. G03w.734.871w.790.600w.850w.500w
  4. G04.434.500w.500w
  5. G05.308w.670.600w.850w.500w

AMA Style

References

  1. National Library of Medicine. Endoplasmic Reticulum-Associated Degradation. Medical Subject Headings (MeSH). 2026. Unique ID D060746. http://id.nlm.nih.gov/mesh/2026/D060746
  2. Endoplasmic Reticulum-Associated Degradation. In: Wikipedia. https://en.wikipedia.org/wiki/Endoplasmic-reticulum-associated_protein_degradation
  3. Endoplasmic Reticulum-Associated Degradation. In: Wikidata. https://www.wikidata.org/wiki/Q21101062