Phenomena and Processes

Unfolded Protein Response

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

MeSH Record

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Synonyms

5 entry terms
  • Protein Response, Unfolded
  • Protein Responses, Unfolded
  • Response, Unfolded Protein
  • Responses, Unfolded Protein
  • Unfolded Protein Responses

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Protein Folding (1995-2009)

MeSH Hierarchy

Tree Numbers

  1. G02.111.660.871w.790.600w.962w
  2. G02.111.691.600w.850w
  3. G03w.734.871w.790.600w.850w
  4. G04.434.500w
  5. G05.308w.670.600w.850w

AMA Style

References

  1. National Library of Medicine. Unfolded Protein Response. Medical Subject Headings (MeSH). 2026. Unique ID D056811. http://id.nlm.nih.gov/mesh/2026/D056811
  2. Unfolded Protein Response. In: Wikipedia. https://en.wikipedia.org/wiki/Unfolded_protein_response
  3. Unfolded Protein Response. In: Wikidata. https://www.wikidata.org/wiki/Q14633900