Chemicals and Drugs

EphA1 Receptor

The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

4 entry terms
  • EPHA1 Protein
  • EPHA1 Receptor Tyrosine Kinase
  • Eph Receptor
  • Receptor, EphA1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use RECEPTOR, EPHA1 (NM) 1999-2002

MeSH Record

Previous Indexing

  • Receptor Protein-Tyrosine Kinases (1999-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.850w.050
  2. D12.776w.476.568w.400w.850w.050
  3. D12.776w.543w.750w.630w.500w.050

AMA Style

References

  1. National Library of Medicine. EphA1 Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D036082. http://id.nlm.nih.gov/mesh/2026/D036082
  2. EphA1 Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q21101171