Chemicals and Drugs

Erythromycin

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Chemical Identity

Chemical Information

Molecular Formula
C37H67NO13
Molecular Weight
733.9 g/mol
CAS Registry No.
114-07-8
IUPAC Name
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
InChIKey
ULGZDMOVFRHVEP-RWJQBGPGSA-N
SMILES
CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
MeSH Unique ID
D004917
Source
PubChem CID 12560

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • Erythromycin A
  • Erycette
  • Erymax
  • Erythromycin C
  • Erythromycin Lactate
  • Erythromycin Phosphate
  • Ilotycin
  • T-Stat
  • Lactate, Erythromycin
  • Phosphate, Erythromycin
  • T Stat
  • TStat

MeSH Record

Aspects Covered

26 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D02w.540w.576w.500w.992w

MeSH Record

NLM Classification

QV 350.5.E7

AMA Style

References

  1. National Library of Medicine. Erythromycin. Medical Subject Headings (MeSH). 2026. Unique ID D004917. http://id.nlm.nih.gov/mesh/2026/D004917
  2. Erythromycin. In: Wikipedia. https://en.wikipedia.org/wiki/Erythromycin
  3. Erythromycin. In: Wikidata. https://www.wikidata.org/wiki/Q213511
  4. Erythromycin. In: PubChem Compound. CID 12560. https://pubchem.ncbi.nlm.nih.gov/compound/12560