Chemicals and Drugs

Factor XII

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.

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Synonyms

4 entry terms
  • Coagulation Factor XII
  • Factor 12
  • Factor Twelve
  • Hageman Factor

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Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

66(64)

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Tree Numbers

  1. D08.622w.500w
  2. D12.776w.124w.125.450w
  3. D12.776w.811w.243w.500w
  4. D23.119.450w

AMA Style

References

  1. National Library of Medicine. Factor XII. Medical Subject Headings (MeSH). 2026. Unique ID D005174. http://id.nlm.nih.gov/mesh/2026/D005174
  2. Factor XII. In: Wikipedia. https://en.wikipedia.org/wiki/Factor_XII
  3. Factor XII. In: Wikidata. https://www.wikidata.org/wiki/Q339499