Structured Summary
Abstract
Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
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Synonyms
12 entry terms
- Activated Factor XII
- Blood Coagulation Factor XII, Activated
- Coagulation Factor XIIa
- Factor 12A
- Factor Twelve A
- Factor XII, Activated
- Prekallikrein Activator
- Activator, Prekallikrein
- Factor XIIa, Coagulation
- Hageman-Factor Fragments
- Fragments, Hageman-Factor
- Hageman Factor Fragments
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
/defic = FACTOR XII DEFICIENCY
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History Note
90
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Previous Indexing
- Factor XII (1966-1989)
- Peptide Fragments (1979-1987)
- Serine Proteinases (1988-1989)
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AMA Style
References
- National Library of Medicine. Factor XIIa. Medical Subject Headings (MeSH). 2026. Unique ID D015956. http://id.nlm.nih.gov/mesh/2026/D015956
- Factor XIIa. In: Wikidata. https://www.wikidata.org/wiki/Q100994454