Structured Summary
Abstract
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
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Classification
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MeSH Record
Synonyms
6 entry terms
- Blood Coagulation Factor I
- Coagulation Factor I
- Factor I
- Factor I, Coagulation
- gamma-Fibrinogen
- gamma Fibrinogen
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
a blood coag factor: do not confuse entry term FACTOR I with COMPLEMENT FACTOR I
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AMA Style
References
- National Library of Medicine. Fibrinogen. Medical Subject Headings (MeSH). 2026. Unique ID D005340. http://id.nlm.nih.gov/mesh/2026/D005340
- Fibrinogen. In: Wikipedia. https://en.wikipedia.org/wiki/Fibrinogen
- Fibrinogen. In: Wikidata. https://www.wikidata.org/wiki/Q381899