Fibrinopeptide A

Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.

Molecular Formula

C₆₃H₉₇N₁₉O₂₆

Molecular Weight

1536.6 g/mol

CAS Registry No.

25422-31-5

IUPAC Name

(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-5-[[2-[[(2S)-3-carboxy-1-[[(2S)-1-[[1-[[(2S)-1-[[(2S)-4-carboxy-1-[[2-[[2-[[2-[[(2S)-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid

InChIKey

JWICNZAGYSIBAR-LEEGLKINSA-N

SMILES

C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N

MeSH Unique ID

D005344

Source

PubChem CID 25078015

98(76)

• Fibrinogen (1968-1975)
• Peptides (1968-1975)

1. D12.644w.200
2. D12.776w.124w.125.515
3. D12.776w.124w.270w.310
4. D12.776w.811w.300w.310
5. D23.101w.340
6. D23.119.500

1. National Library of Medicine. Fibrinopeptide A. Medical Subject Headings (MeSH). 2026. Unique ID D005344. http://id.nlm.nih.gov/mesh/2026/D005344
2. Fibrinopeptide A. In: Wikidata. https://www.wikidata.org/wiki/Q76714094
3. Fibrinopeptide A. In: PubChem Compound. CID 25078015. https://pubchem.ncbi.nlm.nih.gov/compound/25078015