Chemicals and Drugs

Fibroblast Growth Factor Type 2 Receptor

A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).

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Synonyms

19 entry terms
  • BEK Fibroblast Growth Factor Receptor
  • BEK Fibroblast Growth Factor Receptor Kinase
  • BEK Protein Tyrosine Kinase
  • Bek Fgf Receptor Kinase
  • Bek-Related Fibroblast Growth Factor-Receptor-1
  • CD332 Antigen
  • FGFR2 Protein
  • Fibroblast Growth Factor Receptor 2
  • Fibroblast Growth Factor Receptors 2
  • Receptor, Fibroblast Growth Factor, Type 2
  • Antigen, CD332
  • Bek Related Fibroblast Growth Factor Receptor 1
  • FGFR2b
  • FGFR2c
  • Fibroblast Growth Factor Receptor 2b
  • Fibroblast Growth Factor Receptor 2c
  • Fibroblast Growth Factor Receptors 2b
  • Receptor, Fibroblast Growth Factor 2b
  • Receptor, Fibroblast Growth Factor 2c

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Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2006(1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.178
  2. D12.776w.476.568w.400w.178
  3. D12.776w.543w.750w.630w.441
  4. D12.776w.543w.750w.750w.400w.370w.750

AMA Style

References

  1. National Library of Medicine. Fibroblast Growth Factor Type 2 Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D051497. http://id.nlm.nih.gov/mesh/2026/D051497
  2. Fibroblast Growth Factor Type 2 Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q5446456