Chemicals and Drugs

Floxuridine

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Chemical Identity

Chemical Information

Molecular Formula
C9H11FN2O5
Molecular Weight
246.19 g/mol
CAS Registry No.
50-91-9
IUPAC Name
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
InChIKey
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O
MeSH Unique ID
D005467
Source
PubChem CID 5790

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 5-FUdR
  • 5-Fluorodeoxyuridine
  • FUdR
  • Fluorodeoxyuridine
  • 5 Fluorodeoxyuridine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

an antiviral & antineoplastic antimetabolite

MeSH Record

History Note

93; was FLUORODEOXYURIDINE 1963-92; FLOXURIDINE was see FLUORODEOXYURIDINE 1976-92

MeSH Hierarchy

Tree Numbers

  1. D03w.383.742.680.852w.300w.350w
  2. D13.570w.230w.430w.432w
  3. D13.570w.685.852w.300w.350w

AMA Style

References

  1. National Library of Medicine. Floxuridine. Medical Subject Headings (MeSH). 2026. Unique ID D005467. http://id.nlm.nih.gov/mesh/2026/D005467
  2. Floxuridine. In: Wikipedia. https://en.wikipedia.org/wiki/Floxuridine
  3. Floxuridine. In: Wikidata. https://www.wikidata.org/wiki/Q5462356
  4. Floxuridine. In: PubChem Compound. CID 5790. https://pubchem.ncbi.nlm.nih.gov/compound/5790