Chemicals and Drugs

Flunarizine

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Chemical Identity

Chemical Information

Molecular Formula
C26H26F2N2
Molecular Weight
404.5 g/mol
CAS Registry No.
52468-60-7
IUPAC Name
1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
InChIKey
SMANXXCATUTDDT-QPJJXVBHSA-N
SMILES
C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
MeSH Unique ID
D005444
Source
PubChem CID 941361

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Flunarizin
  • Flunarizine Dihydrochloride
  • Flunarizine Hydrochloride
  • R-14950
  • Sibelium
  • Dihydrochloride, Flunarizine
  • Hydrochloride, Flunarizine
  • R 14950
  • R14950

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Cinnarizine/analogs & derivatives (1975-1986)
  • Piperazines (1966-1974)

MeSH Hierarchy

Tree Number

  1. D03w.383.606w.450w

MeSH Record

NLM Classification

QV 151

AMA Style

References

  1. National Library of Medicine. Flunarizine. Medical Subject Headings (MeSH). 2026. Unique ID D005444. http://id.nlm.nih.gov/mesh/2026/D005444
  2. Flunarizine. In: Wikipedia. https://en.wikipedia.org/wiki/Flunarizine
  3. Flunarizine. In: Wikidata. https://www.wikidata.org/wiki/Q416237
  4. Flunarizine. In: PubChem Compound. CID 941361. https://pubchem.ncbi.nlm.nih.gov/compound/941361