Chemicals and Drugs

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

Chemical Identity

Chemical Information

Molecular Formula
C4H3FN2O2
Molecular Weight
130.08 g/mol
CAS Registry No.
51-21-8
IUPAC Name
5-fluoro-1H-pyrimidine-2,4-dione
InChIKey
GHASVSINZRGABV-UHFFFAOYSA-N
SMILES
C1=C(C(=O)NC(=O)N1)F
MeSH Unique ID
D005472
Source
PubChem CID 3385

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

36 entry terms
  • 5-FU
  • 5-Fluorouracil
  • 5FU
  • Fluoruracil
  • 5 Fluorouracil
  • 5-FU Lederle
  • 5-FU Medac
  • 5-Fluorouracil-Biosyn
  • 5-HU Hexal
  • Adrucil
  • Carac
  • Efudex
  • Efudix
  • Fluoro-Uracile ICN
  • Fluoroplex
  • Fluorouracil Mononitrate
  • Fluorouracil Monopotassium Salt
  • Fluorouracil Monosodium Salt
  • Fluorouracil Potassium Salt
  • Fluorouracil-GRY
  • Fluorouracile Dakota
  • Fluorouracilo Ferrer Far
  • Fluracedyl
  • Flurodex
  • Haemato-FU
  • Neofluor
  • Onkofluor
  • Ribofluor
  • 5 FU Lederle
  • 5 FU Medac
  • 5 Fluorouracil Biosyn
  • 5 HU Hexal
  • Dakota, Fluorouracile
  • Fluoro Uracile ICN
  • Fluorouracil GRY
  • Haemato FU

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.383.742.698.875w.404w

MeSH Record

NLM Classification

QV 269

AMA Style

References

  1. National Library of Medicine. Fluorouracil. Medical Subject Headings (MeSH). 2026. Unique ID D005472. http://id.nlm.nih.gov/mesh/2026/D005472
  2. Fluorouracil. In: Wikipedia. https://en.wikipedia.org/wiki/Fluorouracil
  3. Fluorouracil. In: Wikidata. https://www.wikidata.org/wiki/Q238512
  4. Fluorouracil. In: PubChem Compound. CID 3385. https://pubchem.ncbi.nlm.nih.gov/compound/3385