Anatomy

Follicular Dendritic Cells

Non-hematopoietic cells, with extensive dendritic processes, found in the primary and secondary follicles of lymphoid tissue (the B cell zones). They are different from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL STEM CELLS and are negative for class II MHC antigen and do not process or present antigen like the conventional dendritic cells do. Instead, follicular dendritic cells have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY COMPLEXES on their surfaces for long periods for recognition by B-CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Non-hematopoietic cells, with extensive dendritic processes, found in the primary and secondary follicles of lymphoid tissue (the B cell zones). They are different from conventional DENDRITIC CELLS associated with T-CELLS. They are derived from MESENCHYMAL STEM CELLS and are negative for class II MHC antigen and do not process or present antigen like the conventional dendritic cells do. Instead, follicular dendritic cells have FC RECEPTORS and C3B RECEPTORS that hold antigen in the form of ANTIGEN-ANTIBODY COMPLEXES on their surfaces for long periods for recognition by B-CELLS.

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Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • Dendritic Cells, Follicular
  • Dendritic Reticulum Cells, Follicular
  • Dendritic Cell, Follicular
  • Follicular Dendritic Cell

MeSH Record

Aspects Covered

15 allowable subheadings

Indexed with the subheadings chemistry, classification, cytology, drug effects, enzymology, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.

MeSH Record

Indexing Annotation

DENDRITIC CELLS is also available

MeSH Record

History Note

2000; use DENDRITIC CELLS 1987-1999

MeSH Record

Previous Indexing

  • Dendritic Cells (1987-1999)
  • Lymph Nodes (1980-1986)

MeSH Hierarchy

Tree Numbers

  1. A10w.549w.400w.500w.200w
  2. A11w.066w.275w
  3. A15.382w.066w.275w
  4. A15.382w.520w.604w.412w.500w.200w

AMA Style

References

  1. National Library of Medicine. Follicular Dendritic Cells. Medical Subject Headings (MeSH). 2026. Unique ID D020566. http://id.nlm.nih.gov/mesh/2026/D020566
  2. Follicular Dendritic Cells. In: Wikipedia. https://en.wikipedia.org/wiki/Follicular_dendritic_cells
  3. Follicular Dendritic Cells. In: Wikidata. https://www.wikidata.org/wiki/Q2631550