Chemicals and Drugs

Formyl Peptide Receptors

A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

25 entry terms
  • Chemoattractant Receptor
  • Chemotactic Peptide Receptor
  • F-Chemotactic Peptide Receptor
  • FMLP Receptor
  • Formyl Peptide Receptor
  • N-Formylmethionyl Peptide Receptor
  • N-formyl Hexapeptide Receptor
  • Receptor, Chemotactic Peptide
  • Receptors, Formyl Peptide
  • fMet-Leu-Phe Receptor
  • F Chemotactic Peptide Receptor
  • Hexapeptide Receptor, N-formyl
  • N Formylmethionyl Peptide Receptor
  • N formyl Hexapeptide Receptor
  • Peptide Receptor, Chemotactic
  • Peptide Receptor, N-Formylmethionyl
  • Peptide Receptors, Formyl
  • Receptor, Chemoattractant
  • Receptor, F-Chemotactic Peptide
  • Receptor, FMLP
  • Receptor, Formyl Peptide
  • Receptor, N-Formylmethionyl Peptide
  • Receptor, N-formyl Hexapeptide
  • Receptor, fMet-Leu-Phe
  • fMet Leu Phe Receptor

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2004; use RECEPTORS, FORMYL PEPTIDE (NM) 1980-2003

MeSH Record

Previous Indexing

  • Receptors, Immunologic (1980-2003)
  • Receptors, Peptide (1980-2003)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.695w.235w
  2. D12.776w.543w.750w.705w.873w
  3. D12.776w.543w.750w.750w.340w

AMA Style

References

  1. National Library of Medicine. Formyl Peptide Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D044042. http://id.nlm.nih.gov/mesh/2026/D044042
  2. Formyl Peptide Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Formyl_peptide_receptor
  3. Formyl Peptide Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q24782993