Chemicals and Drugs

HIV Envelope Protein gp120

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.

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See Also

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Synonyms

8 entry terms
  • Envelope Glycoprotein gp120, HIV
  • HIV Envelope Glycoprotein gp120
  • HTLV-III gp120
  • env Protein gp120, HIV
  • gp120 Envelope Glycoprotein, HIV
  • gp120(HIV)
  • HTLV III gp120
  • gp120, HTLV-III

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

90

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Previous Indexing

  • Retroviridae Proteins (1986-1989)
  • Viral Envelope Proteins (1983-1989)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.964w.350.520.350w
  2. D12.776w.964w.775.325.164.249w
  3. D12.776w.964w.775.562.500.500w
  4. D12.776w.964w.970w.880.325.164.249w
  5. D23.050w.327.520.350w

MeSH Record

NLM Classification

WC 503

AMA Style

References

  1. National Library of Medicine. HIV Envelope Protein gp120. Medical Subject Headings (MeSH). 2026. Unique ID D015699. http://id.nlm.nih.gov/mesh/2026/D015699
  2. HIV Envelope Protein gp120. In: Wikipedia. https://en.wikipedia.org/wiki/Envelope_glycoprotein_GP120
  3. HIV Envelope Protein gp120. In: Wikidata. https://www.wikidata.org/wiki/Q182506