Chemicals and Drugs

CD4 Antigens

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

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Classification

Broader headings

Related Concepts

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See Also

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Synonyms

17 entry terms
  • Antigens, CD4
  • CD4 Antigen
  • CD4 Molecule
  • CD4 Receptor
  • CD4 Receptors
  • Receptors, CD4
  • Receptors, Surface CD4
  • Surface CD4 Receptor
  • T4 Antigens, T-Cell
  • Antigen, CD4
  • Antigens, T-Cell T4
  • CD4 Receptor, Surface
  • CD4 Receptors, Surface
  • Receptor, CD4
  • Surface CD4 Receptors
  • T-Cell T4 Antigens
  • T4 Antigens, T Cell

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

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Indexing Annotation

for hematodermic CD4/CD56 neoplasm use LYMPHOMA, NON-HODGKIN

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History Note

2018 (1989); use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989

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Previous Indexing

  • Antigens, Differentiation, T-Lymphocyte (1988-1989)
  • Antigens, Surface (1979-1987)
  • Receptors, Antigen, T-Cell (1980-1989)
  • Receptors, Virus (1979-1989)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.705w.852w.420w.810.500
  2. D12.776w.543w.750w.830.700.025
  3. D23.050w.301.264.894.100
  4. D23.101w.100.894.100

MeSH Record

NLM Classification

QW 573

AMA Style

References

  1. National Library of Medicine. CD4 Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D015704. http://id.nlm.nih.gov/mesh/2026/D015704
  2. CD4 Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q24766707