Anatomy

CD4-Positive T-Lymphocytes

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

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Synonyms

12 entry terms
  • CD4-Positive Lymphocytes
  • T4 Cells
  • T4 Lymphocytes
  • CD4 Positive T Lymphocytes
  • CD4-Positive Lymphocyte
  • CD4-Positive T-Lymphocyte
  • Lymphocyte, CD4-Positive
  • Lymphocytes, CD4-Positive
  • T-Lymphocyte, CD4-Positive
  • T-Lymphocytes, CD4-Positive
  • T4 Cell
  • T4 Lymphocyte

MeSH Record

Aspects Covered

15 allowable subheadings

Indexed with the subheadings chemistry, classification, cytology, drug effects, enzymology, immunology, metabolism, microbiology, parasitology, pathology, physiology, radiation effects, transplantation, ultrastructure, virology.

MeSH Record

Indexing Annotation

subpopulations: index specifics if available or coordinate CD4-POSITIVE T-LYMPHOCYTES with T-LYMPHOCYTE SUBSETS; count: coordinate IM with CD4 LYMPHOCYTE COUNT (NIM)

MeSH Record

History Note

95; was T4 LYMPHOCYTES 1989-94

MeSH Record

Previous Indexing

  • T Lymphocytes (1986-1988)

MeSH Hierarchy

Tree Numbers

  1. A11w.118w.637w.555w.567w.569w.200w
  2. A15.145w.229w.637w.555w.567w.569w.200w
  3. A15.382w.490w.555w.567w.569w.200w

AMA Style

References

  1. National Library of Medicine. CD4-Positive T-Lymphocytes. Medical Subject Headings (MeSH). 2026. Unique ID D015496. http://id.nlm.nih.gov/mesh/2026/D015496
  2. CD4-Positive T-Lymphocytes. In: Wikipedia. https://en.wikipedia.org/wiki/T_helper_cell
  3. CD4-Positive T-Lymphocytes. In: Wikidata. https://www.wikidata.org/wiki/Q632518