Chemicals and Drugs

HIV Reverse Transcriptase

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • Reverse Transcriptase, HIV
  • Reverse Transcriptase, Human Immunodeficiency Virus
  • Transcriptase, HIV Reverse

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008

MeSH Record

Previous Indexing

  • RNA-Directed DNA Polymerase (1983-2007)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.445w.308.300w.750.187
  2. D12.776w.964w.775.375.545.875
  3. D12.776w.964w.775.375.750.187
  4. D12.776w.964w.775.562.764.875
  5. D12.776w.964w.900w.750.500.545.875
  6. D12.776w.964w.900w.750.500.750.187
  7. D12.776w.964w.970w.600.850.375.545.875
  8. D12.776w.964w.970w.600.850.375.750.187

AMA Style

References

  1. National Library of Medicine. HIV Reverse Transcriptase. Medical Subject Headings (MeSH). 2026. Unique ID D054303. http://id.nlm.nih.gov/mesh/2026/D054303
  2. HIV Reverse Transcriptase. In: Wikidata. https://www.wikidata.org/wiki/Q78191295