Chemicals and Drugs

HLA-C Antigens

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Class I human histocompatibility (HLA) antigens encoded by a small cluster of structural genes at the C locus on chromosome 6. They have significantly lower immunogenicity than the HLA-A and -B determinants and are therefore of minor importance in donor/recipient crossmatching. Their primary role is their high-risk association with certain disease manifestations (e.g., spondylarthritis, psoriasis, multiple myeloma).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

4 entry terms
  • Antigens, HLA-C
  • HLA-C
  • Antigens, HLA C
  • HLA C Antigens

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • HLA Antigens (1977-1988)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.489.600
  2. D12.776w.395w.550w.489.600
  3. D12.776w.543w.550w.439.600
  4. D23.050w.301.500.100.600
  5. D23.050w.301.500.450w.390
  6. D23.050w.705.552.100.600
  7. D23.050w.705.552.450w.390

AMA Style

References

  1. National Library of Medicine. HLA-C Antigens. Medical Subject Headings (MeSH). 2026. Unique ID D015236. http://id.nlm.nih.gov/mesh/2026/D015236
  2. HLA-C Antigens. In: Wikidata. https://www.wikidata.org/wiki/Q21114962