Structured Summary
Abstract
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
MeSH Record
Classification
Related Concepts
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See Also
MeSH Record
Synonyms
25 entry terms
- Class I Antigen
- Class I Antigens
- Class I Histocompatibility Antigen
- Class I Histocompatibility Antigens
- Class I MHC Protein
- Class I MHC Proteins
- Class I Major Histocompatibility Antigen
- Class I Major Histocompatibility Antigens
- Class I Major Histocompatibility Molecules
- MHC Class I Molecule
- MHC Class I Molecules
- MHC-I Molecules
- MHC-I Peptide
- MHC-I Peptides
- Antigen, Class I
- Antigens, Class I
- I Antigen, Class
- MHC I Molecules
- MHC I Peptide
- MHC I Peptides
- Molecules, MHC-I
- Peptide, MHC-I
- Peptides, MHC-I
- Class I Human Antigens
- Human Class I Antigens
MeSH Record
Aspects Covered
23 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
human & animal
MeSH Record
History Note
89
MeSH Record
Previous Indexing
- HLA Antigens (1978-1988)
- Histocompatibility Antigens (1973-1988)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Histocompatibility Antigens Class I. Medical Subject Headings (MeSH). 2026. Unique ID D015395. http://id.nlm.nih.gov/mesh/2026/D015395
- Histocompatibility Antigens Class I. In: Wikidata. https://www.wikidata.org/wiki/Q66088505