Structured Summary
Abstract
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
MeSH Record
Classification
Broader headings
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MeSH Record
Synonyms
19 entry terms
- HB-EGF
- Heparin-binding EGF-like Growth-Factor
- HB EGF
- Heparin binding EGF like Growth Factor
- Diphtheria Toxin Receptor
- Diphtheria Toxin Receptors
- HB-EGF Precursor
- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
- Receptor, Diphtheria Toxin
- SF HB-EGF
- Short Form HB-EGF
- HB EGF Precursor
- HB-EGF, Short Form
- Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
- Receptors, Diphtheria Toxin
- SF HB EGF
- Short Form HB EGF
- Toxin Receptor, Diphtheria
- Toxin Receptors, Diphtheria
MeSH Record
Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2015
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Heparin-binding EGF-like Growth Factor. Medical Subject Headings (MeSH). 2026. Unique ID D066257. http://id.nlm.nih.gov/mesh/2026/D066257
- Heparin-binding EGF-like Growth Factor. In: Wikidata. https://www.wikidata.org/wiki/Q14914534