Chemicals and Drugs

Heterotrimeric GTP-Binding Proteins

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.

MeSH Record

Classification

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MeSH Record

Synonyms

14 entry terms
  • Heterotrimeric G Protein
  • Heterotrimeric G-Protein
  • Heterotrimeric G-Proteins
  • Heterotrimeric GTP-Binding Protein
  • G Protein, Heterotrimeric
  • G-Protein, Heterotrimeric
  • G-Proteins, Heterotrimeric
  • GTP-Binding Protein, Heterotrimeric
  • GTP-Binding Proteins, Heterotrimeric
  • Heterotrimeric G Proteins
  • Heterotrimeric GTP Binding Protein
  • Heterotrimeric GTP Binding Proteins
  • Protein, Heterotrimeric G
  • Protein, Heterotrimeric GTP-Binding

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

general or unspecified; prefer specifics

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • Adenylate Cyclase (1968-1984)
  • Carrier Proteins (1966-1984)
  • GTP-Binding Proteins (1985-1999)
  • Guanine Nucleotides (1966-1984)
  • Guanosine Triphosphate (1972-1984)
  • Receptors, Cell Surface (1973-1984)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.330.300.200w
  2. D12.776w.157w.325.332w
  3. D12.776w.476.338.200w
  4. D12.776w.543w.325w

AMA Style

References

  1. National Library of Medicine. Heterotrimeric GTP-Binding Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D020962. http://id.nlm.nih.gov/mesh/2026/D020962
  2. Heterotrimeric GTP-Binding Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Heterotrimeric_G_protein
  3. Heterotrimeric GTP-Binding Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q408561