Chemicals and Drugs

High-Temperature Requirement A Serine Peptidase 1

A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

4 entry terms
  • Serine Protease HTRA1
  • HTRA1, Serine Protease
  • High Temperature Requirement A Serine Peptidase 1
  • Protease HTRA1, Serine

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Serine Endopeptidases (2003-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.420
  2. D08.811w.277w.656w.959w.350.420

AMA Style

References

  1. National Library of Medicine. High-Temperature Requirement A Serine Peptidase 1. Medical Subject Headings (MeSH). 2026. Unique ID D000074289. http://id.nlm.nih.gov/mesh/2026/D000074289
  2. High-Temperature Requirement A Serine Peptidase 1. In: Wikidata. https://www.wikidata.org/wiki/Q21103357