Phenomena and Processes

Kazal Motifs

Highly conserved protein domains characteristic of SERINE PROTEASE INHIBITORS, KAZAL TYPE. They generally occur as tandem repeats, with each domain consisting of approximately 60 amino acids that form a large extended amino acid chain, two short ALPHA-HELICES, and a three-stranded anti-parallel BETA-SHEET. Kazal-like domains also occur in the extracellular portions of AGRIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Highly conserved protein domains characteristic of SERINE PROTEASE INHIBITORS, KAZAL TYPE. They generally occur as tandem repeats, with each domain consisting of approximately 60 amino acids that form a large extended amino acid chain, two short ALPHA-HELICES, and a three-stranded anti-parallel BETA-SHEET. Kazal-like domains also occur in the extracellular portions of AGRIN.

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Classification

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Synonyms

7 entry terms
  • Kazal Domain
  • Kazal Domains
  • Kazal Motif
  • Domain, Kazal
  • Domains, Kazal
  • Motif, Kazal
  • Motifs, Kazal

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Amino Acid Motifs (2008-2017)
  • Amino Acid Sequence (2004-2017)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.500.490w

AMA Style

References

  1. National Library of Medicine. Kazal Motifs. Medical Subject Headings (MeSH). 2026. Unique ID D000074161. http://id.nlm.nih.gov/mesh/2026/D000074161
  2. Kazal Motifs. In: Wikipedia. https://en.wikipedia.org/wiki/Kazal_domain
  3. Kazal Motifs. In: Wikidata. https://www.wikidata.org/wiki/Q24721497