Chemicals and Drugs

I-kappa B Kinase

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

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Classification

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MeSH Record

Synonyms

31 entry terms
  • I kappa B Kinase
  • IkappaB Kinase
  • NK-kappa B-Activating Kinase NAK
  • B Kinase, I-kappa
  • Kinase, I-kappa B
  • Kinase, IkappaB
  • NK kappa B Activating Kinase NAK
  • CHUK Kinase
  • Conserved Helix-Loop-Helix Ubiquitous Kinase
  • I Kappa B alpha-Associated Protein Kinase
  • IKBKB
  • IKK 1 Kinase
  • IKK 2 Kinase
  • IKK alpha
  • IKK beta
  • IKK epsilon
  • IKK gamma
  • IKKepsilon
  • IkappaB Kinase alpha
  • IkappaB Kinase beta
  • IkappaB Kinase epsilon
  • IkappaB Kinase gamma
  • IkappaBalpha Kinase
  • NF-kappaB Essential Modifier
  • Conserved Helix Loop Helix Ubiquitous Kinase
  • Essential Modifier, NF-kappaB
  • I Kappa B alpha Associated Protein Kinase
  • Kinase alpha, IkappaB
  • Kinase beta, IkappaB
  • Kinase epsilon, IkappaB
  • NF kappaB Essential Modifier

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1997)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. I-kappa B Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D051550. http://id.nlm.nih.gov/mesh/2026/D051550
  2. I-kappa B Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/IkappaB_kinase
  3. I-kappa B Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q6103519