Structured Summary
Abstract
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
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Synonyms
19 entry terms
- Class Switching
- Ig Class Switching
- Isotype Switching
- Class Switching, Ig
- Class Switching, Immunoglobulin
- Class Switchings
- Class Switchings, Ig
- Class Switchings, Immunoglobulin
- Ig Class Switchings
- Immunoglobulin Class Switchings
- Isotype Switchings
- Switching, Class
- Switching, Ig Class
- Switching, Immunoglobulin Class
- Switching, Isotype
- Switchings, Class
- Switchings, Ig Class
- Switchings, Immunoglobulin Class
- Switchings, Isotype
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Aspects Covered
6 allowable subheadings
Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.
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History Note
94
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Previous Indexing
- Immunoglobulin Isotypes/biosynthesis (1988-1993)
- Immunoglobulins, Heavy-Chain/genetics (1980-1993)
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References
- National Library of Medicine. Immunoglobulin Class Switching. Medical Subject Headings (MeSH). 2026. Unique ID D017578. http://id.nlm.nih.gov/mesh/2026/D017578
- Immunoglobulin Class Switching. In: Wikipedia. https://en.wikipedia.org/wiki/Immunoglobulin_class_switching
- Immunoglobulin Class Switching. In: Wikidata. https://www.wikidata.org/wiki/Q2386881