Structured Summary
Abstract
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
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Synonyms
3 entry terms
- Immunophilin
- Neurophilin
- Neurophilins
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
don't confuse entry term NEUROPHILINS with NEUROPILINS
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History Note
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
MeSH Record
Previous Indexing
- Immunosuppressive Agents (1990-1998)
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AMA Style
References
- National Library of Medicine. Immunophilins. Medical Subject Headings (MeSH). 2026. Unique ID D020104. http://id.nlm.nih.gov/mesh/2026/D020104
- Immunophilins. In: Wikipedia. https://en.wikipedia.org/wiki/Immunophilins
- Immunophilins. In: Wikidata. https://www.wikidata.org/wiki/Q116672