Chemicals and Drugs

Insulin-Like Growth Factor II

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

MeSH Record

Classification

Broader headings

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See Also

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Synonyms

12 entry terms
  • IGF-2
  • IGF-II
  • Insulin Like Growth Factor II
  • Insulin-Like Somatomedin Peptide II
  • Multiplication-Stimulating Activity
  • Multiplication-Stimulating Factor
  • Somatomedin A
  • Somatomedin MSA
  • Factor, Multiplication-Stimulating
  • Insulin Like Somatomedin Peptide II
  • Multiplication Stimulating Activity
  • Multiplication Stimulating Factor

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

1991(1986)

MeSH Record

Previous Indexing

  • Blood Proteins (1966-1985)
  • Growth Substances (1966-1985)
  • Insulin (1966-1985)
  • Peptides (1966-1985)
  • Somatomedins (1973-1985)
  • Sulfation Factor (1971-1972)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.742.500w.002
  2. D12.776w.124w.862w.002
  3. D23.529.742.500w.002

MeSH Record

NLM Classification

QU 107

AMA Style

References

  1. National Library of Medicine. Insulin-Like Growth Factor II. Medical Subject Headings (MeSH). 2026. Unique ID D007335. http://id.nlm.nih.gov/mesh/2026/D007335
  2. Insulin-Like Growth Factor II. In: Wikidata. https://www.wikidata.org/wiki/Q24766729