Structured Summary
Abstract
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
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Synonyms
18 entry terms
- IGF-1 Receptor
- IGF-I Receptor
- Insulin-Like-Growth Factor I Receptor
- Receptor, IGF Type 1
- Receptor, IGF-I
- Receptor, Insulin-Like Growth Factor I
- Receptor, Insulin-Like Growth Factor Type 1
- Receptors, IGF-1
- Receptors, Insulin-Like-Growth Factor I
- IGF 1 Receptor
- IGF I Receptor
- IGF-1 Receptors
- Insulin Like Growth Factor I Receptor
- Receptor, IGF I
- Receptor, IGF-1
- Receptors, IGF 1
- Receptor, IGF Type 1 alpha Subunit
- Receptor, IGF Type 1 beta Subunit
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2000(1993);
MeSH Record
Previous Indexing
- Receptors, Endogenous Substances (1986-1992)
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AMA Style
References
- National Library of Medicine. IGF Type 1 Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D017526. http://id.nlm.nih.gov/mesh/2026/D017526
- IGF Type 1 Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q2005209