Chemicals and Drugs

Interleukin-1 Receptor Accessory Protein

A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • IL-1RAcP
  • Interleukin 1 Receptor Accessory Protein

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

Indexing Annotation

Do not confuse with INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN

MeSH Record

History Note

2007(1996)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.705w.852w.420w.300w.249

AMA Style

References

  1. National Library of Medicine. Interleukin-1 Receptor Accessory Protein. Medical Subject Headings (MeSH). 2026. Unique ID D053577. http://id.nlm.nih.gov/mesh/2026/D053577
  2. Interleukin-1 Receptor Accessory Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21173882