Structured Summary
Abstract
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
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Synonyms
3 entry terms
- JAK-2 Protein Tyrosine Kinase
- JAK2 Protein Tyrosine Kinase
- JAK 2 Protein Tyrosine Kinase
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2007(1992)
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References
- National Library of Medicine. Janus Kinase 2. Medical Subject Headings (MeSH). 2026. Unique ID D053614. http://id.nlm.nih.gov/mesh/2026/D053614
- Janus Kinase 2. In: Wikidata. https://www.wikidata.org/wiki/Q3162114