Structured Summary
Abstract
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
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Synonyms
5 entry terms
- JAK Kinases
- Janus Kinase
- Kinase, Janus
- Kinases, JAK
- Kinases, Janus
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2007
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References
- National Library of Medicine. Janus Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D053612. http://id.nlm.nih.gov/mesh/2026/D053612
- Janus Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/Janus_kinase
- Janus Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q903451