Chemicals and Drugs

Kallikreins

Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

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Classification

Broader headings

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Drug Class

Pharmacological Action

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See Also

MeSH Record

Synonyms

20 entry terms
  • Callicrein
  • Kallidinogenase
  • Kalliginogenase
  • Kallikrein
  • Kinin-Forming Enzyme
  • Kininogenase
  • Enzyme, Kinin-Forming
  • Kinin Forming Enzyme
  • Dilminal
  • Kallikrein A
  • Kallikrein B'
  • Kallikrein Light Chain
  • Padutin
  • alpha-Kallikrein
  • beta-Kallikrein
  • beta-Kallikrein B
  • Light Chain, Kallikrein
  • alpha Kallikrein
  • beta Kallikrein
  • beta Kallikrein B

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/antag permitted but consider KALLIKREIN-TRYPSIN INACTIVATOR

MeSH Record

History Note

2000(1963)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.300w.760.442w
  2. D08.811w.277w.656w.959w.350.442w
  3. D12.776w.124w.125.597w
  4. D23.119.597w

MeSH Record

NLM Classification

QU 136

AMA Style

References

  1. National Library of Medicine. Kallikreins. Medical Subject Headings (MeSH). 2026. Unique ID D007610. http://id.nlm.nih.gov/mesh/2026/D007610
  2. Kallikreins. In: Wikipedia. https://en.wikipedia.org/wiki/Kallikrein
  3. Kallikreins. In: Wikidata. https://www.wikidata.org/wiki/Q423285