Chemicals and Drugs

Prekallikrein

A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

7 entry terms
  • Fletcher Factor
  • Kallikreinogen
  • Plasma Prokallikrein
  • Factor, Fletcher
  • Prokallikrein, Plasma
  • Plasma Prokallikrein A
  • Prokallikrein A, Plasma

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

89(76); was see under KALLIKREINS 1976-88

MeSH Record

Previous Indexing

  • Blood Coagulation Factors (1973-1975)
  • Enzyme Precursors (1973-1975)
  • Kallikrein (1973-1975)

MeSH Hierarchy

Tree Numbers

  1. D08.622w.658w
  2. D08.811w.277w.656w.300w.760.442w.725w
  3. D08.811w.277w.656w.959w.350.442w.725w
  4. D12.776w.124w.125.597w.712w
  5. D12.776w.811w.243w.658w
  6. D23.119.597w.712w

AMA Style

References

  1. National Library of Medicine. Prekallikrein. Medical Subject Headings (MeSH). 2026. Unique ID D011288. http://id.nlm.nih.gov/mesh/2026/D011288
  2. Prekallikrein. In: Wikipedia. https://en.wikipedia.org/wiki/Prekallikrein
  3. Prekallikrein. In: Wikidata. https://www.wikidata.org/wiki/Q7240014