Chemicals and Drugs

Katanin

An enzyme (AAA ATPase) consisting of the 60 kDa ATPase subunit (p60 subunit A1) which severs MICROTUBULES, and an 80 kDa accessory protein (p80 subunit B1), which targets the enzyme to the CENTROSOME. It releases microtubules from the mitotic SPINDLE POLES to allow depolymerization and poleward motion of chromosomes. It is also a regulator of microtubule dynamics in NEURONAL OUTGROWTH.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme (AAA ATPase) consisting of the 60 kDa ATPase subunit (p60 subunit A1) which severs MICROTUBULES, and an 80 kDa accessory protein (p80 subunit B1), which targets the enzyme to the CENTROSOME. It releases microtubules from the mitotic SPINDLE POLES to allow depolymerization and poleward motion of chromosomes. It is also a regulator of microtubule dynamics in NEURONAL OUTGROWTH.

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (1993)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.013w.500.250w
  2. D08.811w.277w.040w.025w.024.250w
  3. D12.776w.157w.025w.750.250w
  4. D12.776w.220.600.450w.325w
  5. D12.776w.631w.560w.338w

AMA Style

References

  1. National Library of Medicine. Katanin. Medical Subject Headings (MeSH). 2026. Unique ID D000074201. http://id.nlm.nih.gov/mesh/2026/D000074201
  2. Katanin. In: Wikipedia. https://en.wikipedia.org/wiki/Katanin
  3. Katanin. In: Wikidata. https://www.wikidata.org/wiki/Q4217154