Chemicals and Drugs

Ketotifen

A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.

Chemical Identity

Chemical Information

Molecular Formula
C19H19NOS
Molecular Weight
309.4 g/mol
CAS Registry No.
34580-13-7
IUPAC Name
2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
InChIKey
ZCVMWBYGMWKGHF-UHFFFAOYSA-N
SMILES
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1
MeSH Unique ID
D007665
Source
PubChem CID 3827

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one
  • Ketotifene
  • Ketotiphen
  • Ketotiphene
  • Ketotifen Fumarate
  • Zaditen
  • Fumarate, Ketotifen

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

82

MeSH Record

Previous Indexing

  • Piperidines (1966-1981)
  • Thiophenes (1966-1981)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.778.370w
  2. D03w.383.621.370w
  3. D03w.383.903.370w

MeSH Record

NLM Classification

QV 157

AMA Style

References

  1. National Library of Medicine. Ketotifen. Medical Subject Headings (MeSH). 2026. Unique ID D007665. http://id.nlm.nih.gov/mesh/2026/D007665
  2. Ketotifen. In: Wikipedia. https://en.wikipedia.org/wiki/Ketotifen
  3. Ketotifen. In: Wikidata. https://www.wikidata.org/wiki/Q2458673
  4. Ketotifen. In: PubChem Compound. CID 3827. https://pubchem.ncbi.nlm.nih.gov/compound/3827