Structured Summary
Abstract
An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
Chemical Identity
Chemical Information
- Molecular Formula
- C12H9F3N2O2
- Molecular Weight
- 270.21 g/mol
- CAS Registry No.
- 75706-12-6
- IUPAC Name
- 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
- InChIKey
- VHOGYURTWQBHIL-UHFFFAOYSA-N
- SMILES
- CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
- MeSH Unique ID
- D000077339
- Source
- PubChem CID 3899
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide
- Arava
- HWA 486
- HWA-486
- SU101
- HWA486
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
2019 (1985)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Leflunomide. Medical Subject Headings (MeSH). 2026. Unique ID D000077339. http://id.nlm.nih.gov/mesh/2026/D000077339
- Leflunomide. In: Wikipedia. https://en.wikipedia.org/wiki/Leflunomide
- Leflunomide. In: Wikidata. https://www.wikidata.org/wiki/Q248550
- Leflunomide. In: PubChem Compound. CID 3899. https://pubchem.ncbi.nlm.nih.gov/compound/3899