Chemicals and Drugs

Leucine-2-Alanine Enkephalin

A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.

Chemical Identity

Chemical Information

Molecular Formula
C29H39N5O7
Molecular Weight
569.6 g/mol
CAS Registry No.
63631-40-3
IUPAC Name
(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
InChIKey
ZHUJMSMQIPIPTF-IBURTVSXSA-N
SMILES
C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
MeSH Unique ID
D016308
Source
PubChem CID 6917707

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

19 entry terms
  • 2-Alanyl-Leucine Enkephalin
  • 5-Leucine-2-Alanine Enkephalin
  • D-Ala(2)-D-Leu(5)-Enkephalin
  • DADLE
  • Enkephalin, Leucine-2-Alanine
  • Enkephalin-Leu,Ala(2)
  • Leu-Enkephalin-2-Ala
  • Leucine Enkephalin-2-Alanine
  • 2 Alanyl Leucine Enkephalin
  • 5 Leucine 2 Alanine Enkephalin
  • Enkephalin, 2-Alanyl-Leucine
  • Enkephalin, 5-Leucine-2-Alanine
  • Enkephalin, Leucine 2 Alanine
  • Enkephalin-2-Alanine, Leucine
  • Leu Enkephalin 2 Ala
  • Leucine Enkephalin 2 Alanine
  • BW-180C
  • BW 180C
  • BW180C

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91

MeSH Record

Previous Indexing

  • Enkephalin, Leucine (1983-1990)
  • Enkephalins (1977-1982)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.400w.575w.281w.231.500w
  2. D12.776w.631w.650w.575w.281w.231.500w

AMA Style

References

  1. National Library of Medicine. Leucine-2-Alanine Enkephalin. Medical Subject Headings (MeSH). 2026. Unique ID D016308. http://id.nlm.nih.gov/mesh/2026/D016308
  2. Leucine-2-Alanine Enkephalin. In: Wikipedia. https://en.wikipedia.org/wiki/DADLE
  3. Leucine-2-Alanine Enkephalin. In: Wikidata. https://www.wikidata.org/wiki/Q424905
  4. Leucine-2-Alanine Enkephalin. In: PubChem Compound. CID 6917707. https://pubchem.ncbi.nlm.nih.gov/compound/6917707