Chemicals and Drugs

Leukemia Inhibitory Factor Receptor alpha Subunit

A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • Antigens, CD118
  • CD118 Antigen
  • CD118 Antigens
  • LIF Receptor alpha Subunit
  • Antigen, CD118

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.705w.852w.583.750
  2. D12.776w.543w.750w.750w.400w.550w.250w.750

AMA Style

References

  1. National Library of Medicine. Leukemia Inhibitory Factor Receptor alpha Subunit. Medical Subject Headings (MeSH). 2026. Unique ID D053680. http://id.nlm.nih.gov/mesh/2026/D053680
  2. Leukemia Inhibitory Factor Receptor alpha Subunit. In: Wikidata. https://www.wikidata.org/wiki/Q6534503