Structured Summary
Abstract
A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
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Synonyms
10 entry terms
- Lissencephalia
- Lissencephalies
- Agyria
- Broad Gyri of Cerebrum
- Large Gyri of Cerebrum
- Macrogyria
- Pachygyria
- Agyrias
- Macrogyrias
- Pachygyrias
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Aspects Covered
34 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
MeSH Record
Indexing Annotation
note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available
MeSH Record
History Note
2008
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AMA Style
References
- National Library of Medicine. Lissencephaly. Medical Subject Headings (MeSH). 2026. Unique ID D054082. http://id.nlm.nih.gov/mesh/2026/D054082
- Lissencephaly. In: Wikipedia. https://en.wikipedia.org/wiki/Lissencephaly
- Lissencephaly. In: Wikidata. https://www.wikidata.org/wiki/Q1544416