Chemicals and Drugs

Loratadine

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

Chemical Identity

Chemical Information

Molecular Formula
C22H23ClN2O2
Molecular Weight
382.9 g/mol
CAS Registry No.
79794-75-5
IUPAC Name
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
InChIKey
JCCNYMKQOSZNPW-UHFFFAOYSA-N
SMILES
CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
MeSH Unique ID
D017336
Source
PubChem CID 3957

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

Synonyms

7 entry terms
  • 4-(8-Chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester
  • Alavert
  • Claritin
  • Clarium
  • Sch-29851
  • Sch 29851
  • Sch29851

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

93; was LORATADINE (NM) 1984-92

MeSH Record

Previous Indexing

  • Cyproheptadine/analogs & derivatives (1987-1992)
  • Piperidines (1984-1986)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.426w.559w.847w.181w.384.340w.500w
  2. D03w.383.621.160w.500w
  3. D04w.615w.181w.384.340w.500w

AMA Style

References

  1. National Library of Medicine. Loratadine. Medical Subject Headings (MeSH). 2026. Unique ID D017336. http://id.nlm.nih.gov/mesh/2026/D017336
  2. Loratadine. In: Wikipedia. https://en.wikipedia.org/wiki/Loratadine
  3. Loratadine. In: Wikidata. https://www.wikidata.org/wiki/Q424049
  4. Loratadine. In: PubChem Compound. CID 3957. https://pubchem.ncbi.nlm.nih.gov/compound/3957